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Test drug did not hamper the erythropoiesis rather enhanced the formation of RBC's suggesting possible therapeutic role of Rasamanikya along with honey and ghee in conditions like anaemia. Role of arsenical compound in blood disorders was also reported earlier [ 32 ].
Result of test drugs on serum biochemical parameters showed significant decrease in blood urea at all dose levels including recovery group of animals. Increase in urea has significant role in toxicity, while low level represents low turnover of protein and nitrogenous material in rats or may be due serious liver toxicity.
This increase in serum creatinine was not observed at higher dose levels and in animals under recovery study in comparison to control or VC groups. Total protein level was unaffected at all doses. Albumin level was increased while globulin level was decreased by test drugs.
All these values are within normal range. The test drug at all dose levels decreased total cholesterol, while triglycerides and HDL cholesterol were increased in comparison to control group, but no changes were observed when compared to VC group.
This indicates possible interference with the lipid turnover in the experimental animals. HDL plays very important role in preventing the atherogenesis by taking away the cholesterol from the arterial wall and by inhibiting the oxidation of atherogenic lipoproteins [ 33 ].
Decrease in total cholesterol level with concomitant increase in HDL cholesterol may suggest therapeutic utility of Rasamanikya in the hyperlipidemic conditions. Whenever there is injury in organs like liver; SGPT level gets elevated.
Serum aminotransferases are elevated in most liver disorders and these are one of the most reliable markers of hepatocellular injury or necrosis [ 34 ]. In present study, serum transaminases insignificantly increased at lower dose level including VC, however values are within normal range.
All these observed changes are reverted in recovery group and not observed at higher dose level in comparison to control and VC group.
The decrease in bilirubin is still within normal range. The observed serum biochemical changes are mild and within normal ranges, hence it is inferred that drug is devoid of any serious toxic effects on serum biochemical parameters in rats.
Mild to moderate pathological changes in heart, liver, kidney and GI tract at higher dose levels were observed in histopathological study. The observed changes were not seen in group-I, where RM was administered at therapeutic dose, suggesting safety nature of the drug.
The effects of biochemical parameters also match and support the histopathological findings of liver, kidney, stomach and ileum at higher dose level of the test drug validating safety nature of Ayurvedic arsenical formulations. Interestingly, these pathological changes were reversed in the recovery group indicating reversal of drug-induced adverse changes. Main treatment of heavy metal toxicity is to prevent or terminate the exposure [ 35 ].
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Hence, after termination of RM, normal histopathology was appeared in the organs of animals in the recovery group. Though the observed pathological changes were reverted after withdrawal of the drug; it is advisable to administer RM in specified TED along with a suitable vehicle honey and ghee for shorter periods.
Care need to be observed while administering the drug in patients with hepatic, cardiac and renal impairments. It is also inferred that such formulations are not to be administered continuously for a longer period and observing a gap of few days is advisable [ 36 ]. Conflicts of interest There are no conflicts of interest.
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New methods or substantially modified methods may be described in sufficient detail. The statistical method and the level of significance chosen shall be clearly stated. Bhunvara joined as the second Assistant Editor.
The Headquarters of the IPA were shifted to Bombay with effect from 1st January and this helped considerably the publication of this journal and its circulation to members. Khorana resigned as Editor of the journal with effect from 1 January and Dr. Ramasarma succeeded him as the Editor and Mr. Baichwal joined as Assistant Editors. Patel joined as the third Assistant Editor. A detailed history of the Journal was published in the journal IJP,25, The year represented an important milestone in the history of IJP.
Publication of professional and other general articles and Association News was taken over by a new monthly periodical called "Pharma Times" with Mr. Mehta as its Editor.